BPS Pharmacotherapy (Part1 and Part2) : BPS-Pharmacotherapy

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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. An 18-year-old patient presents with abrasions on the hands, knees, and shoulder from a recent bicycle accident. Gram-staining of surgical incision and drainage specimens reveals Gram positive cocci in chains. The patient has necrotizing fasciitis and develops bronchospasms after being given penicillin. Which intravenous antibiotic would be best to use in place of penicillin?

A) Ceftriaxone
B) Clindamycin
C) Ciprofloxacin
D) Sulfamethoxazole/trimethoprim

2. The Randomized Aldactone Evaluation Study (RALES) yielded the following results:
* Placebo death rate: 386/841
* Spironolactone death rate: 284/822
Given these data, which of the following is the relative risk reduction for death with spironolactone, in comparison with placebo?

A) 24%
B) 31%
C) 11%
D) 45%

3. A patient is receiving oxcarbazepine. Which is the most relevant toxicity monitoring parameter?

A) TSH
B) Serum Sodium
C) Serum potassium
D) Serum Creatinine

4. A 50-year-old woman experienced acute renal failure after receiving contrast dye for an imaging study. Her estimated creatinine clearance is now 20 mL/min. Her medications include:
* Piperacillin/tazobactam 4.5g intravenously every 8 hours
* Azithromycin 500 mg intravenously daily
* Famotidine 40 mg orally twice daily
* Enoxaparin 40 mg subcutaneously daily
* Metoprolol succinate 100 mg orally daily
Which drugs require dose reduction due to acute renal failure?

A) Piperacillin/tazobactam, famotidine, and enoxaparin
B) Piperacillin/tazobactam, famotidine, and metoprolol succinate
C) All of her current medications
D) Piperacillin/tazobactam, azithromycin, and enoxaparin

5. A 50-year-old patient is admitted for acute coronary syndrome with a past medical history of hyperlipidemia and diabetes. The patient was transferred to the cardiac care unit for intubation because of worsening condition with increased shortness of breath. Physical examination and laboratory results reveal:
* BP: 140/90 mm Hg
* HR: 90 bpm
* RR:27 bpm
* O2 Sat: 90% on 2L
* Nasal cannula general: moderate distress
* Chest: bibasilar rales noted
* CV: S1, S2 present, + JVD 11 cm
* EXT. bilateral pulses, 2+ pitting edema, warm extremities
* BUN: 40 mg/dL
* Serum creatinine: 2.1 mg/dL
* Brain natriuretic peptide: 1120 pg/mL
Which of the following is the most appropriate first-line intravenous therapy for this patient?

A) Furosemide
B) Nitroprusside
C) Milrinone
D) Metolazone

Solutions: